Taking Dmg And Tmg Together
The dietary supplement dimethylglycine is a derivative of the amino acid glycine. Dimethylglycine forms in the body as well as in plant and animal life. The supplement reportedly may improve athletic performance and the body’s immune system. Foods rich in B vitamins contain at least small amounts of dimethylglycine. Dosages of DMG depend on several factors, and there are few known side.
TRIMETHYLGLYCINE OR TMG
Appart and gives away its methyl groups the body needs folate as an. In the absence of folate DMG can produce formaldehyde. Depending upon your current biochemistry, some people do well on DMG, others on DMG + folate + B12, others on TMG, and some on TMG plus. (TMG - Trimethyglycine - 3 methyl groups). DMG on the other hand is a byproduct of the minor/BHMT pathway, and taking DMG will likely result in suppressing it. So TMG and DMG have opposite effects although they're similar. Edited by rwac, 29 July 2011 - 05:23 AM. TMG consists of three methyl groups (CH3) joined to one molecule of the amino acid glycine. This is a very important type of structure because, when eaten in food or taken orally as a supplement, TMG easily lets go of two or even three of its methyl groups. Letting go of one methyl group leaves a substance called dimethylglycine or DMG. TMG can yeild up to 3 methyl groups however only the conversion of TMG to DMG actually converts Homocysteine back to methionine. The donation of each methylgroup is entirley substrate specific. Only after all 3 are donated, which does not always happen, does TMG yeild free glycine. SAMe is created from methionine not homocysteine. TMG is DMG with an extra methyl group added. Or, that's how I understand it anyway. Some kids have seen good progress with speech and since speech is going very slow with Holden, I decided to ask Dr. David if we could try it. Eminem albums download torrent. Trimethylglycine supplement benefit and dosage, by Ray Sahelian, M.D. September 12 2016. Trimethylglycine TMG (also known as betaine), and dimethylglycine DMG, are methyl donors that help in the production of several brain chemicals and hence improve mood, energy, wellbeing, alertness, concentration, and visual clarity.
Trimethylglycine or TMG is a recent and amazing addition to all nutritional balancing supplement programs. I have been using it since January 2013. TMG is a vitamin-like substance. It functions as an anti-oxidant, anti-inflammatory, energy booster, methyl donor and more.
TMG is also called betaine because it was first isolated from sugar beets. It is not the same as betaine hydrochloride, however. I now add it to most all nutritional balancing programs. The dosage is up to 1000 mg daily for women and up to 3000 mg daily for men. Children need less, depending on their size.
Most people seem to need it and benefit greatly from it. It does not seem to interfere with the rest of a nutritional balancing program, which is very unusual, provided one does not take too much.
Sources are:
1. Plenty of TMG is made in a healthy body.
2. Some can also be obtained from the diet.
3. One can take it as a food supplement that is available in many health food stores.
Not Enough Made by The Body
Many people do not make enough TMG today.The reason appears to be the presence of certain toxic metals.In addition, stress, infections, inflammation and other disease conditions may use up what the body makes, so more is needed.
Mercury Toxicity
Mercury is just one poison that either interferes with TMG production in the body, or increases the body’s need for this amazing chemical.
The problem of mercury toxicity is so widespread that I laugh when people want to be tested for mercury poisoning.I tell them everyone is mercury toxic today because mercury is so widely distributed in the environment.Some are more toxic than others with mercury, but we are all subject to it.If you eat any fish or seafood, toxicity will be much worse.If you have silver/mercury dental amalgams, you will also likely have more of it.Mercury can contribute to hundreds of health conditions.For more on mercury, read Mercury Toxicity.
Copper Toxicity
Copper toxicity may also interfere with TMG.Most people today are toxic with certain forms of copper, regardless of what blood, urine or other tests reveal.In fact, these tests are very unreliable to assess the copper balance, and most people’s bodies contain some toxic forms of copper such as amigo copper.
One cause of the copper toxicity is widespread zinc deficiencies in the soil and in our food.This tends to cause more accumulation of copper in the body.Women tend to be more copper toxic than men, although it affects both men and women.
Copper imbalance is responsible for most headaches, female organ problems, mental health conditions such as depression, anxiety and panic attacks, skin conditions and more.For more on copper, read Copper Toxicity Syndrome on this website.
Dietary Sources of TMG
The main foods high in TMG are broccoli, beets and other vegetables.These foods are naturally high in TMG and in folate, which are both methyl donors.The problem is that most people do not eat nearly enough of these foods to get a sufficient amount of TMG from their diet.Also, even if one eats plenty of these vegetables, it is not nearly enough.So I suggest supplementing it, as well.
Supplements
Supplementary TMG appears to be very helpful due to 1) low production inside the body, 2) a greater need for TMG today, and 3) inadequate dietary intake of TMG. See below for dosages, and cautions with supplementary TMG.
THE BASIC STRUCTURE OF TMG
TMG consists of three methyl groups (CH3) joined to one molecule of the amino acid glycine.This is a very important type of structure because, when eaten in food or taken orally as a supplement, TMG easily lets go of two or even three of its methyl groups.
Letting go of one methyl group leaves a substance called dimethylglycine or DMG.Letting go of three methyl groups frees up a molecule of the amino acid glycine.These are discussed below.
Dimethylglycine
When TMG gives up a methyl group, it leaves a compound called dimethylglycine.Dimethylglycine is considered a B-complex vitamin and has been shown to assist with speech and behavior in autistic children and adults, attention deficit-hyperactivity disorder (ADHD), to improve neurological function, and to reduce seizure activity.It can help one handle stress, improves oxygen utilization, enhances liver activity and helps optimize athletic performance.
DMG also has anti-inflammatory and anti-aging effects.Dimethylglycine is used to improve the immune response, to shrink tumors, and to enhance anti-viral, anti-bacterial, and anti-tumor defenses.It has also been shown to benefit chronic fatigue syndrome, allergies, respiratory disorders, alcoholism, and drug addiction.
In addition, it appears to help reduce serum cholesterol and triglycerides, and to help normalize blood pressure and blood glucose.In short, it is quite amazing.
Note, however, that dimethylglycine is not used as a supplement in nutritional balancing, as it is very yin in Chinese medical terms, which is harmful for a nutritional balancing program. Also, it is not as good as TMG, which has all the benefits of DMG, and more.
Glycine
Glycine is the smallest of the amino acids.This is important in subtle ways.It is very important in the formation of collagen, among other functions.Collagen is the most abundant protein in the human body and used for connective tissue such as tendons, ligaments, cartilage, arteries, veins, and most other similar structures.
Glycine, in larger doses of up to 3000 mg daily, has been found helpful for sleep and alertness.I do not use such large doses, but it could be tried if nothing else works.Perhaps this is why TMG helps some people rest.
FUNCTIONS OF TMG
TMG is useful for the body as a methyl donor.In addition, it has other uses when broken down into DMG and glycine, or transformed into SAMe or other compounds such as methionine.Let us discuss a few of these.
A Powerful & Safe Methyl Donor
TMG easily donates three methyl groups to the body.Methyl groups (CH3) are required in millions of biochemical reactions in human and animal bodies.Here are just a few of the best studied examples:
1. Lowering Homocysteine
Homocysteine is an amino acid that, in excess, is irritating to the arteries and is strongly associated with inflammation and hardening of the arteries.In fact, the level of homocysteine correlates much better with heart disease than the level of cholesterol.
Doctors are beginning to realize this important link.High homocysteine occurs when there is not enough TMG or folic acid to donate enough methyl groups.There can be other causes, but this is the major cause.As explained earlier, a deeper cause for this is the presence of mercury and copper toxicity, which are almost universal.However, the problem can be solved with a diet high in TMG and folate, or a TMG or folate supplement.One does not need both in most cases.
High homocysteine, however, causes many other problems.It causes a deficiency of methionine, and this, in turn, can cause a deficiency of SAMe, causing depression in some people.Methionine is also needed for other biochemical reactions involving protein synthesis, another critical body function.In fact, reducing excessive homocysteine helps with conditions ranging from osteoporosis and birth defects to cancer and aging.It also helps with antioxidant protection, as well.
#2. Helping with Liver Detoxification
Methyl groups are absolutely essential for the Phase 2, P450 liver detoxification pathway.Within this critical biochemical sequence of events, fat-soluble or otherwise poorly soluble toxins that are difficult for the liver to remove are joined to a methyl group, and this helps prepare them for removal from the body. This is an amazing and vital chemical detoxification ability.In MOST people, it does not work well due living in a very toxic world.
Specifically, the methylation reactions enables toxins to become much more soluble in water.This allows the body to remove the toxins much better, and it often neutralizes some of their toxic properties, as well.These toxins include all of the toxic metals in many forms and compounds, as well as hundreds of toxic chemicals.Much more could be written about this amazing system and how critical it is today for our health.This is one of the main benefits of TMG supplementation, I believe.
#3. Alleviating Depression
TMG increases the body’s natural production of SAMe or S-adenosyl methionine.This chemical can help reduce depression, in some cases.SAMe is an expensive supplement, and a more yin supplement, which is not good.It appears to be far better to just take TMG.
#4. Reducing the Chances of Diabetes
Methyl groups are involved in insulin release and insulin activity.When the body does not have enough active methyl groups, diabetes is much more likely to arise.
#5. Avoiding Genetic Problems
Methyl groups are needed for protein synthesis, also called biosynthesis.This is the copying of our genetic code from the DNA to RNA, and then from there the synthesis or formation of every chemical in our bodies.The copying of the DNA is also called genetic transcription.
Without enough TMG, biosynthesis can slow down, telomeres can shorten, and genetic errors, also called transcription errors, multiply, and health is definitely worse.
TMG Has an Overall Parasympathetic Effect
TMG seems to help restore balance to the autonomic nervous system, especially in those who are following a complete nutritional balancing program.This may be one of its most important benefits.
Hair mineral analyses reveal that about half the population has an autonomic nervous system imbalance that I call sympathetic dominance.It means their sympathetic or fight-or-flight nervous system is “on” too much of the time.This is very damaging for anyone’s health.A supplement of TMG can help reverse this imbalance, and thus contribute greatly to healing.For more on this important topic, read Sympathetic Dominance on this website.
Note: Other doctors use the words sympathetic dominance differently, usually to mean a sympathetic state of body chemistry.This is very different and has nothing to do with sympathetic dominance, as the word is used on this website.
TMG Good for Those With an MTHFR Defect
Over 50% of the world’s population today has a mild to severe copying error in their cells that reduces the biosynthesis of folate in their bodies.This is mistakenly called a “genetic defect”, when it is no such thing.It is a transcription error or polymorphism or abnormal gene expression.This is an error in copying the DNA code, and not a problem with the DNA code itself.For more on this, read MTHFR Defects, Genetic Defects and Genetic Testing.
Anti-Oxidant & Anti-Inflammatory Effects
These appear to be true, although I have not seen much medical literature about them.Perhaps more studies will be done on this in the future.
Profound Effects On The Brain, Digestion & Other Body Systems
TMG seems to affect many body systems, probably because methylation reactions are vital throughout the body.
What is most clear from our research, so far, is that it is a wonderful addition to a nutritional balancing program.Dr. Paul Eck, my teacher, would be thrilled with this product.
He always sought to continuously improve nutritional balancing programs to meet the needs of the day, which today means the ability to detoxify hundreds of toxins, about which we sometimes know very little.
Anti-Oxidant and Anti-Inflammatory Effects
These appear to be true, although I have not seen much medical literature about them. Perhaps more studies will be done on this in the future.
Profound Effects on the Brain, Digestion and Other Body Systems.
TMG seems to affect many body systems, probably because methylation reactions are vital throughout the body.What is most clear from our research, so far, is that it is a wonderful addition to a nutritional balancing program. Dr. Paul Eck, my teacher, would be thrilled with this product.
He always sought to continuously improve nutritional balancing programs to meet the needs of the day, which today means the ability to detoxify hundreds of toxins, about which we sometimes know very little.
DOSAGE AND CAUTIONS WITH TMG
For Adults
TMG comes in tablets or capsules of 500, 750 and 1000 mg.Endomet Labs does not sell TMG at this time, but it is widely available in health food stores and on the internet.Do not take DMG or dimethylglycine.Only take trimethylglycine or TMG.
All brands in the stores seem to work well.A few people have complained the NOW brand of TMG picks up moisture and the pills fall apart.This would only occur in a damp climate.However, it still works.
DOSAGE OF TMG
For Adults
TMG comes in tablets or capsules of 500, 750 and 1000 mg. Endomet Labs does not sell TMG at this time, but it is widely available in health food stores and on the internet. Do not take DMG or dimethylglycine. Only take trimethylglycine or TMG.
All brands in the stores seem to work well. A few people have complained that the NOW brand of TMG picks up moisture and the pills fall apart. This would only occur in a damp climate. However, it still works.
Dosage
Figuring out how much TMG to supplement has not been easy. Hair analysis has not been a reliable guide, nor have other standard tests.Recently, we found that women should take only 1000 mg daily. Men can take up to 3000 mg daily.
If one takes too much, usually one does not feel well. Symptoms of too much TMG include some fatigue,nausea, hair loss, dizziness, spaciness or rarely other symptoms. Too much also causes the body to become yin, which is not helpful. This is hard to detect, however.
Giving TMG to Babies & Children
Children need proportionately less TMG than adults, depending on their size and weight.Babies sometimes benefit from 100-200 mg daily.Older children often need about 500-750 mg daily or even more.
TMG is available in a liquid and powder or crystals, and this may be easier to give to children.TMG tastes sweet, so it may be possible to just add it to children’s food.
Cautions with TMG: Most people report no side effects at all from taking TMG.Most just feel better.Often they report a little better sleep and perhaps a little more energy, when starting.
DOSAGE DURING SOME RETRACING REACTIONS
In many instances, taking extra TMG is wonderful to reduce healing reactions and retracing symptoms. If you are having a healing reaction or purification reaction, you may try taking more TMG, as it can help, in some cases.However, do not keep taking more than 1000 mg for women and up to 3000 mg for men for more than a week or so, as it is somewhat yin.
CAUTIONS WITH TMG
Most people report no side effects at all from taking TMG. Most just feel better. Often they report a little better sleep and perhaps a little more energy, when starting. However, there are several cautions:
1. Yin
TMG is a water-soluble substance similar to some B-complex vitamins, most of which tend to be quite yin. This is important because in nutritional balancing science one must avoid most supplements, including especially those that are quite yin. This is the reason to limit TMG intake, as explained earlier in this article.
The reason for avoiding yin foods, yin supplements, and yin procedures, yin lifestyles and yin thinking is that the bodies are already much too yin, and balancing the physics qualities of yin and yang is amazingly helpful for healing the body, mind and soul. For more on this CRITICAL TOPIC, please read Yin and Yang Healing and Yin Disease on this site.
2. A Few People Do Not Tolerate TMG Well
They may just not need very much of it. However, our research indicates that, in some cases, the problem is that it brings up psychological issues or it detoxifies them too quickly.
In particular, men or women who have deep-seated resentments and perhaps some ambivalence about men seem to have more trouble taking TMG. It appears that TMG activates an enzyme system that is dormant or less active in those with male resentment issues. Taking TMG, for these people, can cause rather severe symptoms or anger, fear, depression or anxiety.
If this occurs, just reduce the dosage to a comfortable dose. The symptoms promptly go away when one reduces or stops the TMG. However, if one can tolerate the symptoms, one may move through the retracing of relationship issues much faster, so take what you can.
3. Other Research Reports
These suggest that too much TMG can cause diarrhea and nausea, and may adversely affect the cholesterol level. So far, TMG seems very safe for pregnancy in the doses I suggest.
HOW LONG SHOULD ONE TAKE TMG?
So far, all our clients need to continue taking TMG for several years, at least.This is a subject of research.
IS OVERMETHYLATION A PROBLEM IF ONE TAKES TMG?
A few health authors believe that some people are overmethylated. However, we have not found this to be true, provided that women do not take more than 1000 mg of TMG daily and men do not take over 3000 mg daily. One must also follow the rest of a nutritional balancing diet and healing program.
IF TMG IS SO HELPFUL, WHY IS IT NOT USED MORE OFTEN?
TMG is used by the ton in the poultry and other livestock industries.There it is used as a food additive to help reduce the fat content of the livestock meat, improve the muscle meat, and regulate the amount of feed necessary to produce the best meat.
TMG is not a popular supplement for human beings for several possible reasons:
1. Methylation is Somewhat Complex
Most medical doctors, holistic doctors, nutritionists and naturopaths do not understand it well.For example, some doctors believe that a portion of the population is already overmethylated, and that more methyl groups are harmful.However, I have not observed this.
2. To Lower Homocysteine, most Doctors Suggest a Combination of Supplementary vitamin B6, B12 and Folic Acid Rather than TMG, Even Though TMG May Work Better and is Recommended for Inherited Homocysteinuria
The reason for using B6, B12 and folic acid instead of TMG is that B6 and B12 help move the methyl groups around in certain ways and B6 offers an alternative pathway for the conversion of homocysteine to methionine.I am not sure, at this time, which is best, but both methods work, to the best of my knowledge.
3. Perhaps TMG Helps Those Who Are on a Nutritional Balancing Program More Than it Helps the General Population
Our clients report great benefits, but I have not heard this from those who are not on a nutritional balancing program.I do not know why this would occur, but it may be that TMG works best in combination with the other aspects of a complete nutritional balancing program, for some reason.
4.TMG is Not As Well Known By Many in the Nutrition Professions
This article is designed to help demystify it.
To learn more about methylation and TMG, please read Methylation.
References
1. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol . 2001;96:2711-2717.
2. Angulo P, Lindor KD. Treatment of nonalcoholic fatty liver: present and emerging therapies. Semin Liver Dis. 2001;21:81-188.
3. Barak AJ, Beckenhauer HC, Junnila M, et al. Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res . 1993;17:552-555.
4. Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol and the liver: a review. Alcohol. 1996;13:395-398.
5. Frankel, P. and Madsen, F., Stop Homocysteine Through The Methylation Process, The Research Corner, 1998.
6. Gray ME, Titlow LW. The effect of pangamic acid on maximal treadmill performance. Med Sci Sports Exerc . 1982;14:424-427.
7. Kanbak G, Inal M, Baycu C. Ethanol-induced hepatotoxicity and protective effect of betaine. Cell Biochem Funct. 2001;19:281-285.
8. Mangoni AA, Jackson SH. Homocysteine and cardiovascular disease: current evidence and future prospects. Am J Med. 2002;112:556-565.
9. Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol. 1998;44:249-255.
10. Olthof MR, Van Vliet T, Boelsma E et al. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr . 2003;133:4135-4138.
11. Olthof MR, Vliet TV, Verhoef P et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PLoS Med . 2005;2:e135.
12. Schwab U, Torronen A, Meririnne E et al. Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans. J Nutr . 2005;136:34-38.
13. Wilcken DEL, Dudman NPB, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency—the effects of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985;34:1115-1121.
Sources: Lawrence Wilson, MD © August 2014, The Center For Development
Trimethylglycine supplement benefit and dosage, by Ray Sahelian, M.D.
September 12 2016
Trimethylglycine TMG (also known as betaine), and dimethylglycine DMG, are methyl donors that help in the production of several brain chemicals and hence improve mood, energy, wellbeing, alertness, concentration, and visual clarity.
Taking Dmg And Tmg Together Download
Health benefits
Unless your major is college was chemistry, chances are you don’t remember learning about methyl donors. But if you find the field of mind boosting interesting, you will certainly want to learn more about these supplements. A methyl donor is simply any substance that can transfer a methyl group [a carbon atom attached to three hydrogen atoms (CH3)] to another substance. Many important biochemical processes rely on methylation, including the metabolism of lipids and DNA. Scientists suspect that adequate methylation of DNA can prevent the expression of harmful genes, such as cancer genes. It’s quite likely that our body’s ability to methylate declines with age, potentially contributing to the aging process, and therefore supplementation is an interesting idea in terms of health benefits.
Benefit
Cell Physiol Biochem. 2013. Trimethylglycine is an important human nutrient obtained from a variety of foods and also can be synthesized from choline. It is much more abundant in kidney and liver compared to other mammalian organs. The principal role in the kidney is osmoprotection in cells of the medulla and it enters these cells via the betaine/γ-aminobutyric acid (GABA) transporter protein (BGT1), which is upregulated by hyperosmotic stress. This process has been studied in great detail. In liver, the main role is a methyl donor in the methionine cycle. However, recent studies showed that BGT1 is much more abundant in liver compared to kidney medulla. Despite this, the role of BGT1 in liver has received little attention. Entry of TMG into liver cells is a necessary first step for its action at the cellular level. Increased interest has developed because of a number of therapeutic uses. These include treatment of nonalcoholic fatty liver and hyperhomocysteinemia, a risk factor for atherosclerotic disease. Several important questions need to be addressed to better understand the potential as a therapeutic agent for other liver diseases, such as alcohol-induced injury. Heavy alcohol consumption is the most common cause for liver-related deaths and altered liver metabolism may contribute to hepatic, vascular, coronary, and cerebral diseases.
Taking Dmg And Tmg Together Mod
Mind Power Rx
This natural mind enhancer with trimethylglycine is a sophisticated cognitive formula. It combines a delicate balance of brain circulation agents and neurotransmitter precursors with powerful natural brain chemicals that support:
Memory and Mood
Mental clarity
Concentration
Alertness and Focus
The beneficial herbs in the product are: Ashwagandha, Bacopa, Fo-Ti, Ginkgo biloba, Ginseng, Mucuna pruriens, and Reishi. The nutrients and vitamins in Mind Power Rx include Acetyl-l-carnitine, Carnitine, Carnosine, Choline, DMAE, Inositol, Methylcobalamin, Pantothenic acid, Trimethylglycine, Tyrosine, and Vinpocetine. This brain supplement does not have galantamine or the club moss extract Huperzine A, nor does it haveCDP-choline which raises choline levels.
Research results
Trimethylglycine lowers homocysteine levels.
Has been found to protect liver cells from toxins.
Trimethylglycine is a safe and well tolerated nutrient that leads to a significant biochemical and histological improvement in patients with nonalcoholic steatohepatitis (NASH).
May lead to sexual enhancement and enjoyment, as described in the book Natural Sex Boosters, and there are many other herbal products that have a positive influence for instance Tribulus Terrestris Extract.
Taking Dmg And Tmg Together Login
Depression
Q. You have mentioned in your book, Mind Boosters that DMG and Trimethylglycine are possibly capable of providing much of the same anti-depressant actions as SAM-e, for less cost. I read somewhere that the action of a dose of SAM-e may be enhanced by taking some MSM at the same time. My guess is that would be due to an increase in methylation. Do you think that taking some MSM along with DMG or Trimethylglycine would likewise increase the effects of the DMG or Trimethylglycine?
A. You ask a good question. I have tried finding scientific studies on MSM but the published information on this nutrient is limited. I don't know too much about MSM's cognitive effects, although it is known that it can easily cross the blood-brain barrier. My brief personal experience with this nutrient for a few days did not indicate that it had much effect on mood--unlike DMG, Trimethylglycine, and SAM-e--but I need to emphasize that my experience was very limited. If you do try the combination of MSM with other methyl donors, please let me know if you find a synergistic effect. In the meantime, if I come across any other information, I will make sure to post it. If anyone has tried the combination, please email to me.
Int J Gen Med. 2015. Preliminary results of a randomized controlled trial carried out with a fixed combination of S-adenosyl-L-methionine and betaine versus amitriptyline in patients with mild depression. S-adenosyl-L-methionine (SAMe), a safe, endogenous, pleiotropic methyl donor well known for its antidepressant role, has been assumed to have a possible role in increasing plasma levels of compounds known to be able to raise cardiovascular risk. Although the issue is still being debated, betaine (trimethylglycine TMG), a specific methyl donor involved in the homocysteine circuit, may be able to reduce such a risk and/or, by determining a sparing effect on endogenous SAMe, may be able to improve the clinical efficiency of SAMe itself. Indeed, preliminary results have shown clinical improvement determined by an add-on therapy with betaine administered along with SAMe, versus SAMe alone, to patients affected by mild/moderate depression. This small, open-label, randomized, observational study enrolled 64 individuals with a diagnosis of mild depression. After randomization, they were treated with either Laroxyl (amitriptyline, 75 mg/day) or DDM Metile (enteric-coated SAMe, 500 mg/day, plus TMG, 250 mg/day) for 12 months. After 3 months, both treatments showed a small and not statistically significant improvement. After 6 and 12 months, both treated groups demonstrated a more noticeable improved response, although the group treated with SAMe plus betaine showed better results in terms of score, number of individuals in remission, and side effects. Compliance was overlapping in both treatments. The association of SAMe plus TMG seems to be a safe and effective tool to counteract mild depression and also when used as monotherapy in subjects with a recent diagnosis.
Additonal nutrients and herbs that help with energy levels include:
B vitamins can be used at a dosage of one to three times the RDA. A great daily multivitamin supplement is MultiVit Rx formulated by Dr. Ray Sahelian.
Bee Pollen can increase energy in many people.
Carnitine can be used at a dosage of 200 to 500 mg a day. It is best not to combine many supplements together since overstimulation can occur. Learn how each supplement works by itself.
Chromium is often used by those with blood sugar elevation.
Creatine is the best muscle booster available.
Ginseng is probably the best known Chinese herb.
Royal Jelly increases energy.
Spirulina is a form of blue green algae.
NADH is a form of the vitamin niacin and available as a supplement.
Q. I am wondering which has the more benefits as far as energy go, DMG or TMG? Also, are they to be taken with food or without for max benefits?
A. DMG is usually available under the tongue and works quicker. They both can be taken with or without food. TMG usually provides more energy but each person is unique in their response.
Side effects, safety, risk, danger
Trimethylglycine, if taken in high dosages, such as more than 750 mg, can cause nausea, increased body temperature, restlessness and insomnia and perhaps muscle tension headache.
Prog Biophys Mol Biol. 2015. Consequences of dietary methyl donor supplements: Is more always better? Several diseases increasing in frequency are associated with altered DNA methylation. DNA methylation is accomplished through metabolism of methyl donors such as folate, vitamin B12, methionine, betaine (trimethylglycine), and choline. Increased intake of these compounds correlates with decreased neural tube defects, although this mechanism is not well understood. Consumption of these methyl donor pathway components has increased in recent years due to fortification of grains and high supplemental levels of these compounds (e.g. vitamins, energy drinks). Additionally, people with mutations in one of the enzymes that assists in the methyl donor pathway (5-MTHFR) are directed to consume higher amounts of methyl donors to compensate. Recent evidence suggests that high levels of methyl donor intake may also have detrimental effects. Individualized medicine may be necessary to determine the appropriate amounts of methyl donors to be consumed, particularly in women of child bearing age.
My son is taking a tmg supplement. Initially, in combination with b12 shots and folate it made a huge difference in his cognitive abilities. Now, when he goes to take a nap, sometimes he can't stop talking, or moving, could his body now be producing this on it's own and additional supplementation is too much? He is 2 and 4 months.
It is easy for children to overdose on this nutrient.
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My experience with trimethylglycine pills
I definitely notice a sense of wellbeing, alertness, and mental sharpness from both trimethylglycine and DMG, generally at a dose between 100 to 500 mg. One morning I took three 750 mg pills of trimethylglycine (totaling 2250 mg) on an empty stomach with an ounce of fruit juice just to see if there were any side effects. An hour later I felt the onset of mild nausea. Drinking a few ounces of milk relieved the nausea. As the day progressed, I felt more energetic and realized that my mood was enhanced. In the evening I took my routine three-mile walk and noticed that I had a great deal of energy. I kept walking and ended up covering, twice my normal distance. The drawback was that at bedtime I was still alert and couldn’t sleep at all. I got out of bed several times throughout the night. I continued feeling the alertness well into the morning of the next day. Apparently 2,250 mg is a very high dose and can have effects on the brain lasting more than twenty-four hours. A positive effect from taking DMG or trimethylglycine that I hadn’t expected was an enhancement in libido. When I take a sublingual form of DMG, I notice the onset of alertness within a half-hour.
The Chemistry of DMG and Trimethylglycine
DMG (dimethylglycine) is basically the amino acid glycine attached to two methyl groups while TMG, also known as betaine, has three methyl groups.Commonly these methyl groups are added to homocysteine, converting it into the amino acid methionine which is then converted to SAMe, a nutrient available over the counter which has been used as a powerful antidepressant. DMG plays a crucial role in the respiratory cycle of the cells, transporting oxygen and serving as a potent methyl donor. DMG acts as a building block for the synthesis of many important substances such as choline, SAM-e, the amino acid methionine, several hormones, neurotransmitters, and DNA. The formation of the neurotransmitters norepinephrine and dopamine requires a methyl group donated by SAMe. Dopamine enhances sex drive.
Recommendations
Trimethylglycine and DMG are underutilized nutrients that hold a great deal of promise but unfortunately, few doctors are familiar with these nutrients. At this time the clinical uses of Trimethylglycine and DMG are not well defined and whether they would be helpful in the therapy of Alzheimer and Parkinson’s disease is not known. Since the body’s ability to methylate declines with age, supplements in small amounts, such as 50 to 100 mg a day, may benefit middle aged and older individuals. I recommend not exceeding 250 mg of Trimethylglycine or DMG on a daily basis until more is known about these supplements. Your dose of trimethylglycine and DMG should be reduced if you are taking B vitamins, SAMe, DMAE, or choline since all of these nutrients have overlapping functions.
Trimethylglycine Research
Trimethylglycine (Betaine) supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects.
Am J Clin Nutr. 2002.
Betaine ( trimethylglycine ) is found in several tissues in humans. It is involved in homocysteine metabolism as an alternative methyl donor and is used in the treatment of homocystinuria in humans. In pigs, trimethylglycine decreases the amount of adipose tissue. The aim of the study was to examine the effect of trimethylglycine supplementation on body weight, body composition, plasma homocysteine concentrations, blood pressure, and serum total and lipoprotein lipids. Forty-two obese, white subjects (14 men, 28 women) treated with a hypoenergetic diet were randomly assigned to a trimethylglycine-supplemented group (6 g/d) or a control group given placebo for 12 wk. The intervention period was preceded by a 4-wk run-in period with a euenergetic diet. Body weight, resting energy expenditure, and fat mass decreased significantly in both groups with no significant difference between the groups. Plasma homocysteine concentrations decreased in the trimethylglycine group. Diastolic blood pressure decreased without a significant difference between the groups. Serum total and LDL-cholesterol concentrations were higher in the trimethylglycine group than in the control group. A hypoenergetic diet with trimethylglycine supplementation (6 g daily for 12 wk) decreased the plasma homocysteine concentration but did not affect body composition more than a hypoenergetic diet without trimethylglycine supplementation did.
Taking Dmg And Tmg Together Ual
questions
Q. I've just read about Trimethyglycine on your site. I recently had blood work done and everything was great except my Homocysteine, which was 11.1. I want to lower it to the 6-7 range. I've been researching and found sites with TMG protocols of up to 6 grams along with B6 (100-500 mg), B12 (1000-3000 mcg), and folic acid (800-5000 mcg). My question: Does taking these supplements at these dosages have side effects? Especially the TMG, which is very high? One site mentioned someone who had a Homocysteine number of 18. He took TMG at 6 grams and 500 mg of B6 and lowered it to 4 in 60 days. I'm just curious as to your opinion of these kind of dosages. Your thoughts are appreciated. Your site is very informative.
A. TMG at high doses can increase body temperature and cause irritability and insomnia. My preference is not to use TMG in a dosage greater than 750 mg daily. Also, massive doses of B vitamins are not required. A fraction of the doses mentioned in your email can be effective. Each person is unique in their response, though, and some require less, others more.
I find that TMG in a high doses stimulates my brain too much. Even 500 mg seems to be too high for me.
Yes, trimethylglycine can cause stimulation in some people even at a dose of 100 mg.
Do you know how much 2000 mg of TMG is in SAM-e supplement?
TMG and SAM-e are different molecules even though they are both methyl donors. TMG is trimethylglycine while SAM-e is s-adenosyl-methionine. Even though they have similar actions, they are different molecules. It's hard to know what the equivalence is in terms of potency, but a very rough guess would be that sam-e is a few times (3 to 6 times?) more potent than TMG.
I take a few herbs for health and medical conditions including ahcc product for immune system, serrapeptase supplement as an antioxidant, mangosteen fruit extract, graviolafruit extract and I take trimethylglycine for sexual enhancement. Am I taking too many supplements, could these cause side effects in the long run?
I prefer people not mix too may pills in one day unless they have tried each one separately and know the benefits and side effects quite well. It is difficult to predict interactions since that depends on the dosages used and your particular physiology and tolerance to herbs and pills.
I need to take as 2,000 much of TMG daily for mood, lower doses don't seem to work as well. I have read that if you take TMG at 2000 mg you need over 1000 mg of folic acid. Folic acid in high doses has been link to a certain cancer. Could you tell me if I only take 400 mg or 800 mg of folic (along with B6 and B12) with 2000 TMG is my homocystiene likely to be too high. I am to get a test soon so I will know. But I wanted to know what you might know.
I am not aware that there have been any studies that say folic acid supplements are required in those who take TMG in high dosages. There are other options to treat depression naturally.
Thank you for your research and teaching on this website! I have benefitted from the information here several times. I especially appreciate the mix of your personal experience, the emperical studies, anecdotal evidence, and your analysis of the usefulness and applicability of the information from the various sources. Will TMG (375mg every other day) increase my total cholestrol or lower my HDL:LDL ratio? I am a 53yr old male with a good HDL:LDL due to much exercise and avoiding transfats, and slightly elevated total cholestrol. While I am interested in the health benefits of TMG, I really do not want to increase total cholestrol or lower my HDL:LDL ratio. While I realise that there is little science on this at the moment, what would be your guess on the typical effect of supplementation?
Chances are low dosages of this natural supplement will not have much of an influence on cholesterol levels, it is not easy to make such predictions accurately. It is a good idea to take breaks from the use of TMG pills.
Trimethylglycine is said to be the supreme methylating compound and has been used by some in combination with other methylators e.g. folinic / folic acid, B12 to help 'lift a blockage' within the 'methylation' cycle. If however the supplimentation with trimethylglycine were to induce a headache which increased in severity with the ingestion of food, would this likely suggest a blockage due to a deficient co-factor/co-enzyme, or a state of 'over-methylation' for which supplementation with methylation agents would be detrimental?
It is not clear to me why TMG causes headaches in higher dosages, but the simplest thing to do is reduce the dosage or use it less frequently.
First of all, thanks for all the amazing information and research on your web site. I want to ask you a few questions regarding TMG. I've read somewhere that this natural supplement is an inexpensive alternative to SAM-e, since the body can make SAM-e directly from TMG -- is this accurate? If so, how much TMG is equivalent to 200 mg of SAM-e?
Although TMG helps with mood, it is not as effective as SAM-e to treat depression but nevertheless is of benefit. It's difficult to give equivalence ratios, but I would guess 200 mg of SAM-e would be in some ways as strong as 400 to 1000 mg of TMG but their effects are not all similar. This is a rough guess and varies among individuals.
Buy TMG supplement 500 mg Jarrow Formulas
Buy TMG trimethylglycine 500 mg
| Supplement Facts | ||
| Serving Size: 1 Tablet | ||
| Servings Per Container: 120 | ||
| Amount Per Serving | % DV | |
| Trimethylglycine (Anhydrous Betaine) | 500 mg | * |
| * Daily Value not established. | ||
Dosage: half a tablet in the morning a few times a week
buy Trimethylglycine supplement, 750 mg by Source Naturals
TMG is found in a variety of plant and animal sources and is used in the conversion of homocysteine to methionine. TMG has been shown to help protect the liver and raise S-adenosylmethionine (SAM-e) levels, in animal studies.
Amount Per Serving:
Calcium- 60 mg - 6%DV
Trimethylglycine 750 mg
Dosage: a third or half tablet in the morning a few times a week. High dosages are not advised to be taken regularly.